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| PROPAFENONE HYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 54063-53-5
(Base) 34183-22-7 (Hydrochloride) |
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| EINECS NO. | 258-955-6, 251-867-9 | |
| FORMULA | C21H27NO3·HCl | |
| MOL WT. | 377.91 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | ||
| 1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone; 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
white to off-white crystalline powder |
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| MELTING POINT | 171 - 174 C | |
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Slightly soluble | |
| pH | 5.0 - 6.5 | |
| VAPOR DENSITY |
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| AUTOIGNITION |
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REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions. |
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GENERAL DESCRIPTION & APPLICATIONS |
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| Propafenone, structurally similarities to beta-blocking agents, is a sodium channel blocker by slowing the influx of sodium ions into the cardiac muscle cells; used in the treatment of atrial and life-threatening arrhythmias. It decreases the rate of cardiac conduction and increases the ventricular refractory period. It acts on the Purkinje fibers and myocardium. The chemical designation is 1-[2-[2-hydroxy-3-(propylamino)propoxy] phenyl]- 3-phenylpropan-1-one. The hydrochloride salt of propafenone is a white crystalline powder with a very bitter taste; slightly soluble in water, chloroform and alcohol; melting point 171 - 174 C; having short half-life; administered orally. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
white crystalline powder | |
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IDENTIFICATION |
Complies Test A,B |
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| PURITY |
98.0 - 102.0% |
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| MELTING POINT |
171 - 175 C |
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HEAVY METALS |
20ppm max |
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LOSS ON DRYING |
0.5% max |
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RESIDUE OF SOLVENT |
Complies | |
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| OTHER INFORMATION | ||
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